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  1. The most common adverse effects of Nexium are: headache diarrhea, nausea, and flatulence decreased appetite constipation dry mouth or an unusual taste in the side effects of nexium mouth abdominal pain Less commonly, it may lead to : allergic reactions dark urine. Long-Term Use of Nexium Using Nexium for a long period of time may increase the risk of inflammation of the stomach lining, according to the FDA. These are not all the possible side effects with Nexium.